Sunday, October 1, 2023
  • Advertise with us
  • Disclaimer
  • Privacy Policy
  • Sitemap
  • Terms & Conditions
Dailynews journal
No Result
View All Result
  • Home
  • Bizarre
  • Entertainment
  • Gaming
  • General Knowledge
  • Health
  • Lifestyle
  • Science
  • Society
  • Technology
  • Weird Stuffs
  • Home
  • Bizarre
  • Entertainment
  • Gaming
  • General Knowledge
  • Health
  • Lifestyle
  • Science
  • Society
  • Technology
  • Weird Stuffs
No Result
View All Result
Dailynews journal
No Result
View All Result

10 Medicines That Work But We Don’t Know Why

Pharmaceutical companies run exhaustive trials before they can release a drug onto the market. This is a matter of common sense. No one wants a repeat of the thalidomide scandal of the 1950s and ’60s when some women took thalidomide for morning sickness. The result of the “biggest man-made medical scandal ever” was 10,000 children born with severe deformities.

Authorities closely monitor the research and development of new drugs to ensure they are as safe as possible and that doctors, pharmacists, and patients are aware of any possible side effects. But knowing that a drug is effective is not the same as knowing exactly how it works. The body is a complex mechanism that we still don’t fully understand. Here are 10 medicines that work, but we don’t know why.

READ ALSO

10 Surprising Benefits of Laughter That Are Backed by Science

10 Unconventional Wellness Retreats for the Adventurous Soul

Related: Top 10 Bizarre Things Doctors Prescribe Instead of Medicine

10 Abatacept

In 2015, Science magazine reported that some years before, a team of doctors in Cincinnati treated a sick 12-year-old boy. He had a rare genetic disease that wrongly triggered his immune system, causing considerable damage to his lungs and intestinal system. He had been sick for years, and doctors desperately sought a cure.

On this visit to the hospital, the staff assessed him to see if he might benefit from a bone marrow transplant. They decided that their patient was too sick for the procedure. Doctors gave him Abatacept, knowing that it would do him no harm and might ease his pain.

People who take Abatacept will probably know this drug under its brand name Orencia. Doctors usually prescribe it for conditions such as rheumatoid arthritis.

Doctors fully expected the boy in Cincinnati to die, but he returned six months later in better health. The success of this drug, in this case, was a mystery.

9 Tylenol

Also known as acetaminophen, Tylenol is a favorite in American bathroom cabinets. It’s an effective painkiller that is perfectly safe as long as you stick to the suggested dose. Everybody knows Tylenol, but nobody is certain how it works.

There are three possibilities:

  1. It might block an enzyme that makes our bodies feel pain.
  2. It could be working on the endocannabinoid system. If this is true, then Tylenol functions like THC in marijuana which is also effective for pain treatment.
  3. It might be affecting signals from the neurotransmitter serotonin. Serotonin is a chemical that brain cells produce and contributes to many cognitive functions.

It’s perfectly possible that Tylenol is doing all three things at once, or even none of these.

8 Lithium

Bipolar disorder, once known as manic depression, is a lifelong condition that causes mood swings from severe depression to euphoria. Doctors prescribe lithium, under brand names such as Eskalith or Lithobid, as a widely-recognized and effective treatment for the condition.

Lithium can reduce the severity and frequency of mania and cut the risk of suicide when the sufferer is in a depressive state. Sufferers from bipolar disorder can take lithium over a long period as maintenance therapy. A doctor will ensure that their patient keeps a constant lithium level in the body.

We know that lithium acts on the central nervous system, but we are unclear about what it does exactly. It might reinforce those connections in the brain that regulate mood and behavior, smooth out fluctuations, and ensure that the system works more constantly.

Lithium, the same metal that we use in new batteries, is present in trace amounts in biological systems. Nobody knows what it does.

7 Ulipristal

Ulipristal, marketed as Esmya, prevents pregnancy when someone has had unprotected intercourse or their contraceptive has failed. Ulipristal will prevent or delay the release of an egg. However, it may also change the lining of the uterus. It works, but we are not sure how.

A person should take this medicine within five days of having unprotected sex. It is a particular drug that the user should only take because of this specific circumstance. It is important to note that ulipristal has no effect whatsoever on sexually transmitted diseases.

6 Paxlovid

There’s a lot of information floating around on the internet and social media about medications and which ones work or don’t work. People often seek a solution to the condition and are willing to try anything they think might help—including antibiotics that can’t possibly treat a virus. Pharmaceutical companies were rushing to find a medicine that might work on the coronavirus and, at the same time, be cheap and easy to administer. In November 2021, Pfizer announced that their drug, Paxlovid, could cut the hospitalization rate by almost 90%.

Clinical trials showed that Paxlovid was safe, but questions remained. Paxlovid affects an enzyme in the body that helps proteins in the virus develop into their final, dangerous state. Stop the enzyme from working, and you stop the virus from developing. But how it stops this replication is still not understood.

Paxlovid looks very promising, but it includes a drug called ritonavir that can affect how the body metabolizes other drugs. Anyone who takes Paxlovid must inform their doctor if they take medicines for other conditions. The exact effects that Paxlovid might cause are not fully known.

5 Valdecoxib

Under its brand name Bextra, this was a popular treatment for rheumatoid arthritis and related conditions. In 2005, the Food and Drug Administration (FDA) decided that its risks outweighed its benefits and stopped its sale. Bextra was effective but could cause heart, skin, and stomach problems.

Valdecoxib is a good example of a drug that researchers designed to address a particular problem. In a class of NSAIDs called COX-2 inhibitors, it works by somehow stopping the body’s production of a substance that causes pain and inflammation. However, it had broader effects than expected, even though other COX-2 inhibitors didn’t—at least to the same degree. Pharmaceutical companies routinely run trial after trial until they think that they are certain that they know what they are dealing with. This is why it takes so long to get FDA approval. But it can take years for the full range of side effects to emerge.

4 Febuxostat

Gout is an incredibly painful condition. Traditionally, people thought of it as a condition that only affected the rich, but no physical ailment is ever restricted to a specific class of people. Gout results from having too much uric acid in the body, causing crystals to form around the joints.

Febuxostat (under the brand name Uloric, among others) is a long-term treatment that cuts the production of uric acid. Doctors will usually only prescribe febuxostat for sufferers who can’t tolerate allopurinol. They know that the drug is very effective against gout, but what is less well-understood is why some people suffer debilitating side effects. These can include liver problems, pain in the joints, nausea, and skin rash. In some cases, patients suffer from anaphylactic shock, which can be fatal.

3 Tofacitinib

Sold under the most common brand name, Xeljanz, this is another medicine that doesn’t work as its developers had hoped. A doctor might prescribe this medicine to patients with rheumatoid arthritis who can’t tolerate the more widely-used Methotrexate.

Initial clinical trials revealed that a few subjects contracted upper respiratory tract infections, diarrhea, and headaches. After years of trials, the FDA approved the drug in 2012. Then, in 2014, a study showed that tofacitinib also converted white fat tissues into brown. Brown fat tissues are more active and break down more easily than white. This unexpected result suggested that the drug might be an effective obesity treatment. If this were true, it would suggest that the already expensive drug had an enormous potential market.

It also suggests that researchers didn’t really know how the drug worked. Some patients ended up with cancer or pulmonary embolisms. It’s worth pointing out that these side effects are very rare, but they do occur.

2 Paroxetine

You might know this medicine under its common brand names, Seroxat or Paxil. It is an antidepressant, but doctors may prescribe it for various disorders, such as obsessive-compulsive disorder, panic attacks, posttraumatic stress, and social anxiety. It is also a useful treatment for premature ejaculation and menopausal hot flashes.

Paroxetine is a selective serotonin reuptake inhibitor. This mouthful might suggest that scientists know what it does. Well, yes and no. They know that paroxetine is effective, but they are not sure why. The best guess is that it increases the level of serotonin in the brain. The body produces serotonin from an essential amino acid called tryptophan.

Such foods as cheese, nuts, and red meat contain tryptophan. Your general well-being depends on having an optimal level of serotonin in your system. This chemical affects your physiological functions, behavior, cognition, learning, memory, and mood. Researchers don’t really know how paroxetine works because they don’t fully understand the complex functions of serotonin.

1 Aspirin

Aspirin’s popularity dipped in the sixties as other painkillers came onto the market. But then scientists realized that “aspirin” wasn’t just a painkiller. It was also very effective as a blood thinner and could reduce the likelihood of heart attacks or strokes. Some doctors suggest that regular use of low-strength aspirin may be beneficial, though others are cautious.

Recent research in Sweden suggests that aspirin has another beneficial effect. With access to a database that contained details of 80,000 cancer patients, a Swedish team discovered that if a patient with colon or lung cancer had regularly taken low-strength aspirin before diagnosis, his tumor tended to be less advanced. Doctors can deal with less-advanced tumors more effectively.

This correlation was sufficiently marked that the team was sure that the link was not due to a statistical anomaly. The puzzle now was to work out why aspirin might have this effect. The jury is still out, but it could be that aspirin’s anti-inflammatory properties slow the damage to DNA that can lead to cancer.

Related Posts

10 Surprising Benefits of Laughter That Are Backed by Science
Health

10 Surprising Benefits of Laughter That Are Backed by Science

10 Unconventional Wellness Retreats for the Adventurous Soul
Health

10 Unconventional Wellness Retreats for the Adventurous Soul

Top Ten Morning Routines of Highly Successful People
Health

Top Ten Morning Routines of Highly Successful People

Top 10 Worst Alternative Health Practices Influencers Pedal
Health

Top 10 Worst Alternative Health Practices Influencers Pedal

10 Misconceptions about Mental Health We Need to Unlearn
Health

10 Misconceptions about Mental Health We Need to Unlearn

10 Unsettling Facts about the World’s Deadliest Diseases
Health

10 Unsettling Facts about the World’s Deadliest Diseases

Next Post
10 Times the Rich and Powerful Tried to Top Each Other

10 Times the Rich and Powerful Tried to Top Each Other

Trending

10 Common Activities That Turned into Tragic Freak Accidents

10 Common Activities That Turned into Tragic Freak Accidents

Top 10 Controversial Celebrity Interviews of All Time

Top 10 Controversial Celebrity Interviews of All Time

10 Optical Illusions That Will Blow Your Brain

10 Optical Illusions That Will Blow Your Brain

Top 10 Female Characters Who Are Terrible but Hilarious

Top 10 Female Characters Who Are Terrible but Hilarious

Ten Things You Know about Cowboys That Are Totally Wrong

Ten Things You Know about Cowboys That Are Totally Wrong

10 Remarkable Stories of People Who Escaped the Rat Race

10 Remarkable Stories of People Who Escaped the Rat Race

10 Bizarre Research Projects from the 2023 Ig Nobel Prizes

10 Bizarre Research Projects from the 2023 Ig Nobel Prizes

10 Surprising Benefits of Laughter That Are Backed by Science

10 Surprising Benefits of Laughter That Are Backed by Science

Ten Tales from the Cuban Missile Crisis

Ten Tales from the Cuban Missile Crisis

10 Innovative Ways That Beavers Can Save the World

10 Innovative Ways That Beavers Can Save the World

  • Advertise with us
  • Disclaimer
  • Privacy Policy
  • Sitemap
  • Terms & Conditions

© 2021 Copyrights - All rights reserved.

xoso xoso tin chelsea thông tin chuyển nhượng câu lạc bộ bóng đá arsenal bóng đá atalanta bundesliga cầu thủ haaland UEFA everton xoso futebol ao vivo futemax multicanais onbet bóng đá world cup bóng đá inter milan tin juventus benzema la liga clb leicester city MU man city messi lionel salah napoli neymar psg ronaldo serie a tottenham valencia AS ROMA Leverkusen ac milan mbappe napoli newcastle aston villa liverpool fa cup real madrid premier league Ajax bao bong da247 EPL barcelona bournemouth aff cup asean football bên lề sân cỏ báo bóng đá mới bóng đá cúp thế giới tin bóng đá Việt UEFA báo bóng đá việt nam Huyền thoại bóng đá giải ngoại hạng anh Seagame tap chi bong da the gioi tin bong da lu trận đấu hôm nay việt nam bóng đá tin nong bong da Bóng đá nữ thể thao 7m 24h bóng đá bóng đá hôm nay the thao ngoai hang anh tin nhanh bóng đá phòng thay đồ bóng đá bóng đá phủi kèo nhà cái onbet bóng đá lu 2 thông tin phòng thay đồ the thao vua app đánh lô đề dudoanxoso xổ số giải đặc biệt hôm nay xổ số kèo đẹp hôm nay ketquaxoso kq xs kqxsmn soi cầu ba miền soi cau thong ke sxkt hôm nay thế giới xổ số xổ số 24h xo.so xoso3mien xo so ba mien xoso dac biet xosodientoan xổ số dự đoán vé số chiều xổ xoso ket qua xosokienthiet xoso kq hôm nay xoso kt xổ số mega xổ số mới nhất hôm nay xoso truc tiep xoso Việt SX3MIEN xs dự đoán xs mien bac hom nay xs miên nam xsmientrung xsmn thu 7 con số may mắn hôm nay KQXS 3 miền Bắc Trung Nam Nhanh dự đoán xổ số 3 miền dò vé số du doan xo so hom nay ket qua xo xo ket qua xo so.vn trúng thưởng xo so kq xoso trực tiếp ket qua xs kqxs 247 số miền nam s0x0 mienbac xosobamien hôm nay số đẹp hôm nay số đẹp trực tuyến nuôi số đẹp xo so hom qua xoso ketqua xstruc tiep hom nay xổ số kiến thiết trực tiếp xổ số kq hôm nay so xo kq trực tuyen kết quả xổ số miền bắc trực tiếp xo so miền nam xổ số miền nam trực tiếp trực tiếp xổ số hôm nay ket wa xs KQ XOSO xoso online xo so truc tiep hom nay xstt so mien bac trong ngày KQXS3M số so mien bac du doan xo so online du doan cau lo xổ số keno kqxs vn KQXOSO KQXS hôm nay trực tiếp kết quả xổ số ba miền cap lo dep nhat hom nay soi cầu chuẩn hôm nay so ket qua xo so Xem kết quả xổ số nhanh nhất SX3MIEN XSMB chủ nhật KQXSMN kết quả mở giải trực tuyến Giờ vàng chốt số Online Đánh Đề Con Gì dò số miền nam dò vé số hôm nay so mo so de bach thủ lô đẹp nhất hôm nay cầu đề hôm nay kết quả xổ số kiến thiết toàn quốc cau dep 88 xsmb rong bach kim ket qua xs 2023 dự đoán xổ số hàng ngày Bạch thủ đề miền Bắc Soi Cầu MB thần tài soi cau vip 247 soi cầu tốt soi cầu miễn phí soi cau mb vip xsmb hom nay xs vietlott xsmn hôm nay cầu lô đẹp thống kê lô kép xổ số miền Bắc quay thử xsmn xổ số thần tài Quay thử XSMT xổ số chiều nay xo so mien nam hom nay web đánh lô đề trực tuyến uy tín KQXS hôm nay xsmb ngày hôm nay XSMT chủ nhật xổ số Power 6/55 KQXS A trúng roy cao thủ chốt số bảng xổ số đặc biệt soi cầu 247 vip soi cầu wap 666 Soi cầu miễn phí 888 VIP Soi Cau Chuan MB độc thủ de số miền bắc thần tài cho số Kết quả xổ số thần tài Xem trực tiếp xổ số XIN SỐ THẦN TÀI THỔ ĐỊA Cầu lô số đẹp lô đẹp vip 24h soi cầu miễn phí 888 xổ số kiến thiết chiều nay XSMN thứ 7 hàng tuần Kết quả Xổ số Hồ Chí Minh nhà cái xổ số Việt Nam Xổ Số Đại Phát Xổ số mới nhất Hôm Nay so xo mb hom nay xxmb88 quay thu mb Xo so Minh Chinh XS Minh Ngọc trực tiếp hôm nay XSMN 88 XSTD xs than tai xổ số UY TIN NHẤT xs vietlott 88 SOI CẦU SIÊU CHUẨN SoiCauViet lô đẹp hôm nay vip ket qua so xo hom nay kqxsmb 30 ngày dự đoán xổ số 3 miền Soi cầu 3 càng chuẩn xác bạch thủ lô nuoi lo chuan bắt lô chuẩn theo ngày kq xo-so lô 3 càng nuôi lô đề siêu vip cầu Lô Xiên XSMB đề về bao nhiêu Soi cầu x3 xổ số kiến thiết ngày hôm nay quay thử xsmt truc tiep kết quả sxmn trực tiếp miền bắc kết quả xổ số chấm vn bảng xs đặc biệt năm 2023 soi cau xsmb xổ số hà nội hôm nay sxmt xsmt hôm nay xs truc tiep mb ketqua xo so online kqxs online xo số hôm nay XS3M Tin xs hôm nay xsmn thu2 XSMN hom nay xổ số miền bắc trực tiếp hôm nay SO XO xsmb sxmn hôm nay 188betlink 188 xo so soi cầu vip 88 lô tô việt soi lô việt XS247 xs ba miền chốt lô đẹp nhất hôm nay chốt số xsmb CHƠI LÔ TÔ soi cau mn hom nay chốt lô chuẩn du doan sxmt dự đoán xổ số online rồng bạch kim chốt 3 càng miễn phí hôm nay thống kê lô gan miền bắc dàn đề lô Cầu Kèo Đặc Biệt chốt cầu may mắn kết quả xổ số miền bắc hôm Soi cầu vàng 777 thẻ bài online du doan mn 888 soi cầu miền nam vip soi cầu mt vip dàn de hôm nay 7 cao thủ chốt số soi cau mien phi 777 7 cao thủ chốt số nức tiếng 3 càng miền bắc rồng bạch kim 777 dàn de bất bại on news ddxsmn 188bet w88 w88 789bet tf88 sin88 suvip sunwin tf88 five88 12bet sv88 vn88 Top 10 nhà cái uy tín sky88 iwin lucky88 nhacaisin88 oxbet m88 vn88 w88 789bet iwin f8bet rio66 rio66 lucky88 oxbet vn88 188bet 789bet May-88 five88 one88 sin88 bk8 8xbet oxbet MU88 188BET SV88 RIO66 ONBET88 188bet M88 M88 SV88 Jun-68 Jun-88 one88 iwin v9bet w388 OXBET w388 w388 onbet onbet onbet onbet88 onbet88 onbet88 onbet88 onbet onbet onbet onbet qh88 mu88 Nhà cái uy tín pog79 vp777 vp777 vipbet vipbet uk88 uk88 typhu88 typhu88 tk88 tk88 sm66 sm66 me88 me88 8live 8live 8live sm66 me88 win79 8live sm66 me88 win79 pog79 pog79 vp777 vp777 uk88 uk88 tk88 tk88 luck8 luck8 kingbet86 kingbet86 k188 k188 hr99 hr99 123b 8xbetvn vipbet sv66 zbet taisunwin-vn typhu88 vn138 vwin vwin vi68 ee88 1xbet rio66 zbet vn138 i9betvip fi88club cf68 onbet88 ee88 typhu88 onbet onbetkhuyenmai 12bet-moblie 12betmoblie taimienphi247 vi68clup cf68clup vipbet i9bet qh88 onb123 onbef soi cầu nổ hũ bắn cá đá gà đá gà game bài casino soi cầu xóc đĩa game bài giải mã giấc mơ bầu cua slot game casino nổ hủ dàn đề Bắn cá casino dàn đề nổ hũ tài xỉu slot game casino bắn cá đá gà game bài thể thao game bài soi cầu kqss soi cầu cờ tướng bắn cá game bài xóc đĩa AG百家乐 AG百家乐 AG真人 AG真人 爱游戏 华体会 华体会 im体育 kok体育 开云体育 开云体育 开云体育 乐鱼体育 乐鱼体育 欧宝体育 ob体育 亚博体育 亚博体育 亚博体育 亚博体育 亚博体育 亚博体育 开云体育 开云体育 棋牌 棋牌 沙巴体育 买球平台 新葡京娱乐 开云体育 mu88 qh88
No Result
View All Result
  • Home
  • Bizarre
  • Entertainment
  • Gaming
  • General Knowledge
  • Health
  • Lifestyle
  • Science
  • Society
  • Technology
  • Weird Stuffs

© 2021 Copyrights - All rights reserved.

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Cookie settingsACCEPT
Privacy & Cookies Policy

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Non-necessary
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.
SAVE & ACCEPT